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Glucose (Glu) 346 Reference range 70-143 mg/dL

Histopathological diagnosis

【 diagnosis 】
Gallbladder: Mild proliferative catarrhal cholecystitis

[Findings]
Gallbladder: The mucosa is mildly thickened with tubular and papillary hyperplasia of tall, columnar epithelial cells without atypia. The epithelial cells are actively producing mucus, and yellow-brown pigment (like lipofuscin) is seen in the cytoplasm. The lamina propria is rarely infiltrated with very small numbers of lymphocytes and plasma cells. There are no significant changes in the gallbladder wall.

[Additional Notes]
Cholecystitis is thought to be caused by intestinal bacteria that reflux from the duodenum through the common bile duct, or bacteria that arrive via the bloodstream from the nearby hepatic circulation (Pathology of domestic animals, 6th ed., MG Maxie et al.eds., Vol.2 p.306-307, 2016, Elsevir). Since no bacteria themselves were found in the specimen in this case, there may have been stimulation by bacterial antigens.

【 diagnosis 】
liver:
Hepatocellular glycogen degeneration
Miniaturization of hepatic lobule

[Findings]
Liver: The average diameter of the hepatic lobules is about 1 mm, which is below the reference range (1.5-2 mm). The interlobular veins are rather small in the Glisson's capsule. The hepatocytes are normal in size and show diffuse, mild glycogen degeneration. The sinusoids are congested. No significant changes are observed in the central vein or capsule.

[Additional Notes]
Glycogen degeneration of hepatocytes is a finding suggesting endogenous (stress, hyperadrenocorticism, etc.) or exogenous (long-term administration of steroids, etc.) hyperglucocorticoidemia. There were findings in the liver suggesting primary portal vein hypoplasia, but this level is unlikely to have any clinical impact.